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5AM VENTURES

5AM VENTURES is a Pre-seed, Seed, Series A and Series C+ fund in the US writing $250K–$20M checks into Healthcare, biopharmaceuticals, drug-delivery-technologies, life-science-instruments, drug-delivery, therapeutic-innovations, rare-diseases, genetic-medicines, respiratory-diseases, oncology, immunology and inflammation.

Stages
Pre-seed, Seed, Series A, Series C+
Sectors
Healthcare, biopharmaceuticals, drug-delivery-technologies, life-science-instruments, drug-delivery, therapeutic-innovations, rare-diseases, genetic-medicines, respiratory-diseases, oncology, immunology, inflammation
Check size
$250K–$20M
Invests in
US-wide
Round role
Leads rounds
Actively investing
Yes
Founded
2002
Assets under management
$450M

Thesis

5AM Ventures is a venture capital firm focused on funding and building next-generation life sciences companies. The firm invests in biopharmaceuticals, drug delivery technologies, life science instruments, and therapeutic innovations across major therapeutic areas, including rare diseases, genetic medicines, respiratory diseases, oncology, immunology, and inflammation. They are also interested in digital health with a deep science foundation. The firm primarily invests in early-stage private therapeutic companies, with a strong emphasis on Series A financing, and also invests pre-Series A through their 4:59 Initiative. 5AM Opportunities II focuses on small and mid-cap public and later-stage private biotech and life science companies. The firm manages $450 million from 5AM Ventures VII and $300 million from 5AM Opportunities II. Check sizes range from $500K to $20M+, with Series A typically ranging from $2M to $15M, and the 4:59 Initiative ranging from $250K to $2M.

Common questions

Does 5AM VENTURES invest at the Pre-seed stage?

Yes. 5AM VENTURES lists Pre-seed, Seed, Series A and Series C+ among the stages it invests in.

What check size does 5AM VENTURES write?

5AM VENTURES writes $250K–$20M checks.

Where does 5AM VENTURES invest?

5AM VENTURES invests in the US.

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