SPRUCE CAPITAL PARTNERS
SPRUCE CAPITAL PARTNERS is a Seed, Series A, Series B, debt and other fund in the US and Europe writing $10M–$50M checks into Healthcare, agtech, food-agtech, synthetic-biology and real-estate.
- Stages
- Seed, Series A, Series B, debt, other
- Sectors
- Healthcare, agtech, food-agtech, synthetic-biology, real-estate
- Check size
- $10M–$50M
- Invests in
- US-wide, Europe
- Actively investing
- Yes
- Founded
- 2007
- Assets under management
- $556M
- Website
- sprucecp.com
Thesis
Spruce Capital Partners is a multifaceted investment firm founded in 2007, with distinct entities focusing on real estate and life sciences. The real estate arm, comprising S3 Capital and Spruce Properties, targets middle-market construction lending and multi-family housing assets nationwide, having transacted over 7,500 units and originated over $8.5 billion in loans. The venture capital arm, operating as Spruce Capital Partners, LLC since 2013, invests in early-stage life sciences companies (biotech, healthcare, agtech, food-agtech, synthetic biology) in North America, from seed to Series B, with typical check sizes of $10-50 million. Spruce Street Capital LP, established in 2024, is a New York-based adviser focused on small-cap public and private life sciences companies in North America and Europe. The firm co-manages the MLS Capital Fund II ($150M raised, $200M target) and has approximately $556 million in assets under management as of March 1, 2026, through Spruce Street Capital LP.
Common questions
Does SPRUCE CAPITAL PARTNERS invest at the Seed stage?
Yes. SPRUCE CAPITAL PARTNERS lists Seed, Series A, Series B, debt and other among the stages it invests in.
What check size does SPRUCE CAPITAL PARTNERS write?
SPRUCE CAPITAL PARTNERS writes $10M–$50M checks.
Where does SPRUCE CAPITAL PARTNERS invest?
SPRUCE CAPITAL PARTNERS invests in the US and Europe.